3-BROMO-6-METHYLPICOLINIC ACID

Base Information

• Chemical Name: 3-BROMO-6-METHYLPICOLINIC ACID
• CAS No.: 779344-30-8
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216.034
• Hs Code.: 2933399090
• Mol file: 779344-30-8.mol

Synonyms:3-Bromo-6-methylpyridine-2-carboxylicacid

Chemical Property of 3-BROMO-6-METHYLPICOLINIC ACID

Chemical Property:

• Boiling Point: 314.0±42.0 °C(Predicted)
• PKA: 2.36±0.10(Predicted)
• PSA: 50.19000
• Density: 1.692±0.06 g/cm3(Predicted)
• LogP: 1.85070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-6-methylpicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-6-METHYLPICOLINIC ACID

There total 3 articles about 3-BROMO-6-METHYLPICOLINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-bromo-6-methylpyridine-2-carbonitrile (717843-48-6) → 3-bromo-6-methyl-2-pyridinecarboxylic acid (779344-30-8)

Guidance literature:

With sodium hydroxide; In ethanol; at 90 ℃; Inert atmosphere;

Reference yield:

5-bromo-2-methylpyridine (3430-13-5) → 3-bromo-6-methyl-2-pyridinecarboxylic acid (779344-30-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 20 - 25 °C

2: triethylamine / acetonitrile / 100 °C

3: hydrogenchloride / 110 °C

With hydrogenchloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In chloroform; acetonitrile;

Reference yield:

5-bromo-2-methyl-pyridine-N-oxide (31181-64-3) → 3-bromo-6-methyl-2-pyridinecarboxylic acid (779344-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 100 °C

2: hydrogenchloride / 110 °C

With hydrogenchloride; triethylamine; In acetonitrile;

upstream raw materials:

3-bromo-6-methylpyridine-2-carbonitrile

5-bromo-2-methylpyridine

5-bromo-2-methyl-pyridine-N-oxide

Downstream raw materials:

3-bromo-6-methyl-2-pyridinecarboxaldehyde

Refernces

• 1、 -. "Preparation method of 3-bromo-6-methyl-2-pyridylaldehyde". Paragraph 0003; 0028. . Retrieved 2016/12/12.
• 2、 -. "SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS". Paragraph 0145. . Retrieved 2014/09/30.