(3S,3aS,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3-(6-methyl-pyridin-3-yl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

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Chemical Name:(3S,3aS,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3-(6-methyl-pyridin-3-yl)-hexahydro-pyrano[3,4-b]pyrrol-7-one
CAS No.:109552-78-5
Molecular Formula:C₂₈H₃₀N₂O₃
Molecular Weight:442.558
Hs Code.:

Synonyms:(3S,3aS,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3-(6-methyl-pyridin-3-yl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

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Chemical Property of (3S,3aS,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3-(6-methyl-pyridin-3-yl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

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Technology Process of (3S,3aS,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3-(6-methyl-pyridin-3-yl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

There total 6 articles about (3S,3aS,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3-(6-methyl-pyridin-3-yl)-hexahydro-pyrano[3,4-b]pyrrol-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1-Benzyl-aziridine-2-carboxylic acid (Z)-(R)-1-benzyloxymethyl-4-(6-methyl-pyridin-3-yl)-but-3-enyl ester

: 109552-78-5
(3S,3aS,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3-(6-methyl-pyridin-3-yl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Guidance literature:: In 1,2-dichloro-benzene; at 200 ℃; for 1.5h;
DOI:10.1021/ja00252a037

Reference yield:

: 14618-80-5
(R)-benzyl glycidol

: 109552-78-5
(3S,3aS,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3-(6-methyl-pyridin-3-yl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h / 1.) -70 deg C, 2.) r.t.

2: 85 percent / H₂, quinoline / Lindlar catalyst / benzene / 24 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 2 h / 0 °C

4: CH₂Cl₂ / 2 h / 0 °C

5: 73 percent / 1,2-dichloro-benzene / 1.5 h / 200 °C

With quinoline; hydrogen; triethylamine; Lindlar's catalyst; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; 1,2-dichloro-benzene; benzene;
DOI:10.1021/ja00252a037

Reference yield:

: C₈H₆LiN

: 109552-78-5
(3S,3aS,5R,7aR)-1-Benzyl-5-benzyloxymethyl-3-(6-methyl-pyridin-3-yl)-hexahydro-pyrano[3,4-b]pyrrol-7-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; hexamethylphosphoric acid triamide / 8 h / 1.) -70 deg C, 2.) r.t.

2: 85 percent / H₂, quinoline / Lindlar catalyst / benzene / 24 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 2 h / 0 °C

4: CH₂Cl₂ / 2 h / 0 °C

5: 73 percent / 1,2-dichloro-benzene / 1.5 h / 200 °C

With quinoline; hydrogen; triethylamine; Lindlar's catalyst; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; 1,2-dichloro-benzene; benzene;
DOI:10.1021/ja00252a037