(S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-chlorophenyl)cyclopent-3-ene-1,3-dicarboxylate

Base Information

Chemical Name:(S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-chlorophenyl)cyclopent-3-ene-1,3-dicarboxylate
CAS No.:1264519-67-6
Molecular Formula:C₃₁H₂₇ClO₄
Molecular Weight:499.006
Hs Code.:

Synonyms:(S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-chlorophenyl)cyclopent-3-ene-1,3-dicarboxylate

Suppliers and Price of (S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-chlorophenyl)cyclopent-3-ene-1,3-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-chlorophenyl)cyclopent-3-ene-1,3-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-chlorophenyl)cyclopent-3-ene-1,3-dicarboxylate

There total 2 articles about (S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-chlorophenyl)cyclopent-3-ene-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1264518-96-8
phenanthren-9-yl 2-(4-chlorophenyl)acrylate

: 189078-68-0
tert-butyl buta-2,3-dienoate

: 1264519-67-6
(S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-chlorophenyl)cyclopent-3-ene-1,3-dicarboxylate

Guidance literature:: With 1,1,1-trichloro-2-methyl-propan-2-yl (S)-1-[(2R,3S)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)-butan-2-ylamino]-3,3-dimethyl-1-oxobutan-2-ylcarbamate; In toluene; at 20 ℃; for 0.166667h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja1106282

Reference yield:

: 101492-44-8
ethyl 2-(4-chlorophenyl)acrylate

: 1264519-67-6
(S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-chlorophenyl)cyclopent-3-ene-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 1 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

3: 1,1,1-trichloro-2-methyl-propan-2-yl (S)-1-[(2R,3S)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)-butan-2-ylamino]-3,3-dimethyl-1-oxobutan-2-ylcarbamate / toluene / 0.17 h / 20 °C / Inert atmosphere

With dmap; 1,1,1-trichloro-2-methyl-propan-2-yl (S)-1-[(2R,3S)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)-butan-2-ylamino]-3,3-dimethyl-1-oxobutan-2-ylcarbamate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In dichloromethane; water; toluene;
DOI:10.1021/ja1106282