4-Methyl-benzenesulfinic acid [(Z)-2-cyano-3-phenyl-prop-2-en-(E)-ylidene]-amide

Base Information

• Chemical Name: 4-Methyl-benzenesulfinic acid [(Z)-2-cyano-3-phenyl-prop-2-en-(E)-ylidene]-amide
• CAS No.: 214540-68-8
• Molecular Formula: C₁₇H₁₄N₂OS
• Molecular Weight: 294.377
• Mol file: 214540-68-8.mol

Synonyms:4-Methyl-benzenesulfinic acid [(Z)-2-cyano-3-phenyl-prop-2-en-(E)-ylidene]-amide

Chemical Property of 4-Methyl-benzenesulfinic acid [(Z)-2-cyano-3-phenyl-prop-2-en-(E)-ylidene]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 4-Methyl-benzenesulfinic acid [(Z)-2-cyano-3-phenyl-prop-2-en-(E)-ylidene]-amide

There total 1 articles about 4-Methyl-benzenesulfinic acid [(Z)-2-cyano-3-phenyl-prop-2-en-(E)-ylidene]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate (1517-82-4) + 2-Cyano-3-phenylpropenal (56069-64-8) → 4-Methyl-benzenesulfinic acid [(Z)-2-cyano-3-phenyl-prop-2-en-(E)-ylidene]-amide (214540-68-8)

Guidance literature:

With acetic acid; cesium fluoride; lithium hexamethyldisilazane; Yield given; Multistep reaction; 1.) THF, RT, 1 h; 2.) THF, -78 deg C; 3.) THF, 0 deg C, 14 h;

DOI:10.1002/(sici)1099-0690(199808)1998:8<1629::aid-ejoc1629>3.0.co;2-y

Reference yield:

tert-butyl vinyl ether (926-02-3) + 4-Methyl-benzenesulfinic acid [(Z)-2-cyano-3-phenyl-prop-2-en-(E)-ylidene]-amide (214540-68-8) → (4R,6R)-6-tert-Butoxy-4-phenyl-1-((S)-toluene-4-sulfinyl)-1,4,5,6-tetrahydro-pyridine-3-carbonitrile + (4S,6R)-6-tert-Butoxy-4-phenyl-1-((S)-toluene-4-sulfinyl)-1,4,5,6-tetrahydro-pyridine-3-carbonitrile + (4R,6S)-6-tert-Butoxy-4-phenyl-1-((S)-toluene-4-sulfinyl)-1,4,5,6-tetrahydro-pyridine-3-carbonitrile + (4S,6S)-6-tert-Butoxy-4-phenyl-1-((S)-toluene-4-sulfinyl)-1,4,5,6-tetrahydro-pyridine-3-carbonitrile

Guidance literature:

In dichloromethane; for 48h; under 8250660 Torr; Product distribution; Ambient temperature; different dienophiles and pressures;

DOI:10.1002/(sici)1099-0690(199808)1998:8<1629::aid-ejoc1629>3.0.co;2-y

Reference yield:

1,1-bis(methylthio)ethylene (51102-74-0) + 4-Methyl-benzenesulfinic acid [(Z)-2-cyano-3-phenyl-prop-2-en-(E)-ylidene]-amide (214540-68-8) → (R)-6,6-Bis-methylsulfanyl-4-phenyl-1-((S)-toluene-4-sulfinyl)-1,4,5,6-tetrahydro-pyridine-3-carbonitrile + (S)-6,6-Bis-methylsulfanyl-4-phenyl-1-((S)-toluene-4-sulfinyl)-1,4,5,6-tetrahydro-pyridine-3-carbonitrile

Guidance literature:

In dichloromethane; for 48h; under 8250660 Torr; Yield given; Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1002/(sici)1099-0690(199808)1998:8<1629::aid-ejoc1629>3.0.co;2-y

upstream raw materials:

(1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate

2-Cyano-3-phenylpropenal