3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylamide

Base Information

Chemical Name:3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylamide
CAS No.:1307895-80-2
Molecular Formula:C₂₀H₂₀N₆O₂
Molecular Weight:376.418
Hs Code.:

Synonyms:3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylamide

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Chemical Property of 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylamide

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Technology Process of 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylamide

There total 7 articles about 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 4-amino-7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde

: 107-91-5
cyanoacetic acid amide

: 1307895-80-2
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylamide

Guidance literature:: 4-amino-7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde; cyanoacetic acid amide; With piperidine; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 256.08h;

With hydrogenchloride; In tetrahydrofuran; water; for 1.5h;

Reference yield:

: 1307896-58-7
N'-(3-cyano-4-p-tolyl-1H-pyrrol-2-yl)formimidamide

: 1307895-80-2
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 3 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 4 h

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / Inert atmosphere

5.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

6.1: piperidine / tetrahydrofuran; isopropyl alcohol / 256.08 h / 20 °C

6.2: 1.5 h

With piperidine; sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; tert-butyl alcohol;

Reference yield:

: 1307896-57-6
methyl N-3-cyano-4-p-tolyl-1H-pyrrol-2-ylformimidate

: 1307895-80-2
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonia / methanol / 4 h / 20 °C

2.1: sodium methylate / methanol / 3 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 4 h

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / Inert atmosphere

6.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

7.1: piperidine / tetrahydrofuran; isopropyl alcohol / 256.08 h / 20 °C

7.2: 1.5 h

With piperidine; sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; tert-butyl alcohol;