diethyl [(2E)-3,7-dimethylocta-2,6-dien-1-yl](cyclohexyl)malonate

Base Information

• Chemical Name: diethyl [(2E)-3,7-dimethylocta-2,6-dien-1-yl](cyclohexyl)malonate
• CAS No.: 52567-16-5
• Molecular Formula: C₂₃H₃₈O₄
• Molecular Weight: 378.552
• Mol file: 52567-16-5.mol

Synonyms:diethyl [(2E)-3,7-dimethylocta-2,6-dien-1-yl](cyclohexyl)malonate

Chemical Property of diethyl [(2E)-3,7-dimethylocta-2,6-dien-1-yl](cyclohexyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl [(2E)-3,7-dimethylocta-2,6-dien-1-yl](cyclohexyl)malonate

There total 6 articles about diethyl [(2E)-3,7-dimethylocta-2,6-dien-1-yl](cyclohexyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

diethyl 2-cyclohexylmalonate (2163-44-2) + 1-chloro-3,7-dimethylocta-2,6-diene (5389-87-7) → diethyl [(2E)-3,7-dimethylocta-2,6-dien-1-yl](cyclohexyl)malonate (52567-16-5)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide; In N,N-dimethyl-formamide; at 80 - 100 ℃;

DOI:10.1016/j.mencom.2014.09.002

Reference yield: 53.0%

1-bromocyclohexane (108-85-0) + diethyl [(2E)-3,7-dimethylocta-2,6-dienyl]malonate (19894-79-2) → diethyl [(2E)-3,7-dimethylocta-2,6-dien-1-yl](cyclohexyl)malonate (52567-16-5)

Guidance literature:

With potassium hydroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 105 ℃; for 10h;

DOI:10.1023/B:RUCB.0000035652.61455.b9

Reference yield:

1-chloro-3,7-dimethylocta-2,6-diene (5389-87-7) → diethyl [(2E)-3,7-dimethylocta-2,6-dien-1-yl](cyclohexyl)malonate (52567-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / lithium hydroxide monohydrate; 1-butyl-3-methylimidazolium hexafluorophosphate / 2 h / 20 °C

2: 53 percent / potassium hydroxide; 1-butyl-3-methylimidazolium tetrafluoroborate / 10 h / 105 °C

With potassium hydroxide; lithium hydroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate;

DOI:10.1023/B:RUCB.0000035652.61455.b9

upstream raw materials:

diethyl 2-cyclohexylmalonate

1-bromocyclohexane

diethyl [(2E)-3,7-dimethylocta-2,6-dienyl]malonate

1-chloro-3,7-dimethylocta-2,6-diene

Downstream raw materials:

ethyl (E)-2-cyclohexyl-5,9-dimethyldeca-4,8-dienoate

Cyclohexyl-geranyl-malonsaeure-dibutylester

(E)-2-cyclohexyl-5,9-dimethyldeca-4,8-dienoic acid