(S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester
CAS No.:213480-45-6
Molecular Formula:C₃₀H₄₇N₃O₈
Molecular Weight:577.718
Hs Code.:

(S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester

Synonyms:(S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester

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Technology Process of (S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester

There total 6 articles about (S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 13022-42-9,77167-62-5,84728-06-3,97187-65-0
L-leucyl-L-leucine methyl ester

: 213480-41-2
5-(benzylamino)-5-deoxy-1-O-methyl-2,3-di-O-isopropylidene-β-D-allofuranuronic acid N-carboxy anhydride

: 213480-45-6
(S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jo980354x

Reference yield:

: 33985-40-9
(3aR,4S,6R,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro-[3,4-d][1,3]dioxole-4-carbaldehyde

: 213480-45-6
(S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 4A MS / CH₂Cl₂ / 1 h / 0 °C

2: 5.53 g / triethylamine / toluene; CH₂Cl₂ / 20 °C

3: 97 percent / hydrogen / Pd/C / methanol / 16 h / 20 °C / 760 Torr

4: 91 percent / sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-oxyl; potassium bromide / CH₂Cl₂; aq. phosphate buffer / -5 - 0 °C / pH 7

5: 87 percent / CH₂Cl₂ / 24 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; hydrogen; triethylamine; potassium bromide; palladium on activated charcoal; In methanol; phosphate buffer; dichloromethane; toluene; 1: Condensation / 2: Cycloaddition / 3: Hydrogenolysis / 4: Oxidation / 5: Condensation;
DOI:10.1021/jo980354x

Reference yield:

: 100-46-9
benzylamine

: 213480-45-6
(S)-2-{(S)-2-[(R)-2-Benzylamino-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acetylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 4A MS / CH₂Cl₂ / 1 h / 0 °C

2: 5.53 g / triethylamine / toluene; CH₂Cl₂ / 20 °C

3: 97 percent / hydrogen / Pd/C / methanol / 16 h / 20 °C / 760 Torr

4: 91 percent / sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-oxyl; potassium bromide / CH₂Cl₂; aq. phosphate buffer / -5 - 0 °C / pH 7

5: 87 percent / CH₂Cl₂ / 24 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; hydrogen; triethylamine; potassium bromide; palladium on activated charcoal; In methanol; phosphate buffer; dichloromethane; toluene; 1: Condensation / 2: Cycloaddition / 3: Hydrogenolysis / 4: Oxidation / 5: Condensation;
DOI:10.1021/jo980354x