16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-iodobenzoate

Base Information

• Chemical Name: 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-iodobenzoate
• CAS No.: 1470067-98-1
• Molecular Formula: C₃₀H₃₃IN₂O₃
• Molecular Weight: 596.508
• Mol file: 1470067-98-1.mol

Synonyms:16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-iodobenzoate

Chemical Property of 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-iodobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-iodobenzoate

There total 4 articles about 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.4%

NH-pyrazole (288-13-1) + 16-formyl-17-chloroandrosta-5,16-diene-3β-yl-4-iodobenzoate (1470067-87-8) → 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-iodobenzoate (1470067-98-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.02.031

Reference yield:

4-iodobenzoic acid (619-58-9) → 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-iodobenzoate (1470067-98-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide; dmap / chloroform / 2 h / 20 °C

2: trichlorophosphate / chloroform / 5 h / Reflux; Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

With dmap; caesium carbonate; dicyclohexyl-carbodiimide; trichlorophosphate; In chloroform; N,N-dimethyl-formamide; 2: |Vilsmeier-Haack Formylation;

DOI:10.1016/j.ejmech.2013.02.031

Reference yield:

17-oxaandrost-5-ene-3β-yl p-iodobenzoate (1470067-83-4) → 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-iodobenzoate (1470067-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / chloroform / 5 h / Reflux; Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

With caesium carbonate; trichlorophosphate; In chloroform; N,N-dimethyl-formamide; 1: |Vilsmeier-Haack Formylation;

DOI:10.1016/j.ejmech.2013.02.031

upstream raw materials:

4-iodobenzoic acid

NH-pyrazole

16-formyl-17-chloroandrosta-5,16-diene-3β-yl-4-iodobenzoate

17-oxaandrost-5-ene-3β-yl p-iodobenzoate