Bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide

Base Information

Chemical Name:Bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide
CAS No.:125653-55-6
Molecular Formula:C₁₈H₂₃O₃P
Molecular Weight:318.353
Hs Code.:
DSSTox Substance ID:DTXSID60452783
Wikidata:Q82273610
Mol file:125653-55-6.mol

Synonyms:Bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide;125653-55-6;bis(4-methoxy-3,5-dimethylphenyl)-oxophosphanium;SCHEMBL1305177;DTXSID60452783;JSYUCISYJIGHOR-UHFFFAOYSA-N;FT-0760892

Suppliers and Price of Bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE OXIDE 95.00%
5MG
$ 503.35

Total 2 raw suppliers

Chemical Property of Bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:317.13065656
Heavy Atom Count:22
Complexity:329

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

BIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE OXIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC(=C1OC)C)[P+](=O)C2=CC(=C(C(=C2)C)OC)C

Technology Process of Bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide

There total 4 articles about Bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 14804-38-7
5-bromo-2-methoxy-1,3-dimethylbenzene

: 762-04-9
phosphonic acid diethyl ester

: 125653-55-6
bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide

Guidance literature:: 5-bromo-2-methoxy-1,3-dimethylbenzene; With iodine; magnesium; In tetrahydrofuran; at 25 - 40 ℃; for 2.5h; Inert atmosphere;

phosphonic acid diethyl ester; In tetrahydrofuran; at 20 - 25 ℃; for 15.5h; Inert atmosphere;
DOI:10.1246/bcsj.20210023

Reference yield: 61.0%

: 14804-38-7
5-bromo-2-methoxy-1,3-dimethylbenzene

: 125653-55-6
bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide

Guidance literature:: 5-bromo-2-methoxy-1,3-dimethylbenzene; With iodine; magnesium; In tetrahydrofuran; Inert atmosphere; Reflux;

With sodium hydride; phosphonic acid diethyl ester; In tetrahydrofuran; at 0 ℃; for 1h; Reflux;
DOI:10.1002/chem.202002930

Reference yield: 46.7%

Diethyl phosphonate: 762-04-9,123-22-8
Diethyl phosphonate

: 125653-55-6
bis(4-methoxy-3,5-dimethylphenyl)phosphine oxide

Guidance literature:: With iodine; magnesium; ethylene dibromide; In tetrahydrofuran; at 20 ℃; for 1h;

5-bromo-2-methoxy-1,3-dimethylbenzene; In tetrahydrofuran; at 5 - 40 ℃; for 1h;

Diethyl phosphonate; In tetrahydrofuran; at 5 ℃; for 2h;