Technology Process of tert-butyl-[13-iodo-3-(tetrahydro-pyran-2-yloxy)-tridecyloxy]-diphenyl-silane
There total 8 articles about tert-butyl-[13-iodo-3-(tetrahydro-pyran-2-yloxy)-tridecyloxy]-diphenyl-silane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole; iodine; triphenylphosphine;
In
benzene;
at 10 ℃;
DOI:10.1021/ol034338k
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: NaH / tetrahydrofuran / 0 °C
2.1: i-Bu2AlH / CH2Cl2 / -78 °C
3.1: 82 percent / (-)-diethyl tartrate; titanium(IV) isopropoxide; t-butyl hydroperoxide / molecular sieves 4 Angstroem / CH2Cl2 / -23 °C
4.1: Red-Al / tetrahydrofuran / 0 - 20 °C
4.2: 76 percent / NaIO4 / CH2Cl2; acetone; H2O
5.1: 99 percent / imidazole / dimethylformamide / 0 °C
6.1: 99 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 20 °C
7.1: BH3*SMe2 / tetrahydrofuran / 0 °C
7.2: 87 percent / H2O2; NaOH / tetrahydrofuran; H2O / 0 - 20 °C
8.1: 92 percent / I2; triphenylphosphine; imidazole / benzene / 10 °C
With
1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; dimethylsulfide borane complex; iodine; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; (-)-diethyl tartrate; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride;
4 A molecular sieve;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
1.1: Wittig reaction / 3.1: Sharpless epoxidation;
DOI:10.1021/ol034338k
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: i-Bu2AlH / CH2Cl2 / -78 °C
2.1: 82 percent / (-)-diethyl tartrate; titanium(IV) isopropoxide; t-butyl hydroperoxide / molecular sieves 4 Angstroem / CH2Cl2 / -23 °C
3.1: Red-Al / tetrahydrofuran / 0 - 20 °C
3.2: 76 percent / NaIO4 / CH2Cl2; acetone; H2O
4.1: 99 percent / imidazole / dimethylformamide / 0 °C
5.1: 99 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 20 °C
6.1: BH3*SMe2 / tetrahydrofuran / 0 °C
6.2: 87 percent / H2O2; NaOH / tetrahydrofuran; H2O / 0 - 20 °C
7.1: 92 percent / I2; triphenylphosphine; imidazole / benzene / 10 °C
With
1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; dimethylsulfide borane complex; iodine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; (-)-diethyl tartrate; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride;
4 A molecular sieve;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
2.1: Sharpless epoxidation;
DOI:10.1021/ol034338k
