5-bromo-2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 5-bromo-2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1207968-97-5
• Molecular Formula: C₁₇H₁₅BrF₃N
• Molecular Weight: 370.212
• Mol file: 1207968-97-5.mol

Synonyms:5-bromo-2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 5-bromo-2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-bromo-2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 5-bromo-2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-Trifluoromethylbenzaldehyde (454-89-7) + 5-bromo-1,2,3,4-tetrahydro-isoquinoline (81237-69-6) → 5-bromo-2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline (1207968-97-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield: 92.0%

5-bromo-2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline (1207968-97-5) + [3-(ethoxycarbonyl)phenyl]boronic acid (4334-87-6) → ethyl 3-[2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinolin-5-yl]benzoate (1207968-98-6)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 20h; Inert atmosphere;

upstream raw materials:

3-Trifluoromethylbenzaldehyde

5-bromo-1,2,3,4-tetrahydro-isoquinoline

Downstream raw materials:

ethyl 3-[2-[3-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinolin-5-yl]benzoate