tert-butyl (2R,3S)-2-(3-bromopropyl)-3-({[(1S)-1-(4-hydroxybenzyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-5-methylhexanoate

Base Information

Chemical Name:tert-butyl (2R,3S)-2-(3-bromopropyl)-3-({[(1S)-1-(4-hydroxybenzyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-5-methylhexanoate
CAS No.:191406-78-7
Molecular Formula:C₂₅H₃₈BrNO₆
Molecular Weight:528.484
Hs Code.:

Synonyms:tert-butyl (2R,3S)-2-(3-bromopropyl)-3-({[(1S)-1-(4-hydroxybenzyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-5-methylhexanoate

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Chemical Property of tert-butyl (2R,3S)-2-(3-bromopropyl)-3-({[(1S)-1-(4-hydroxybenzyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-5-methylhexanoate

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Technology Process of tert-butyl (2R,3S)-2-(3-bromopropyl)-3-({[(1S)-1-(4-hydroxybenzyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-5-methylhexanoate

There total 6 articles about tert-butyl (2R,3S)-2-(3-bromopropyl)-3-({[(1S)-1-(4-hydroxybenzyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3417-91-2
L-tyrosine methyl ester HCl

: 191406-77-6
(2R,3S)-6-bromo-3-(tert-butoxycarbonyl)-2-isobutylhexanoic acid

: 191406-78-7
tert-butyl (2R,3S)-2-(3-bromopropyl)-3-({[(1S)-1-(4-hydroxybenzyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-5-methylhexanoate

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm010127e

Reference yield: 75.0%

: 191406-78-7
tert-butyl (2R,3S)-2-(3-bromopropyl)-3-({[(1S)-1-(4-hydroxybenzyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-5-methylhexanoate

Guidance literature:

Reference yield:

: 191406-76-5
Benzyl 3S-(3-bromopropyl)-3-t-butoxycarbonyl-2(R)-isobutylpropanoate

: 191406-78-7
tert-butyl (2R,3S)-2-(3-bromopropyl)-3-({[(1S)-1-(4-hydroxybenzyl)-2-methoxy-2-oxoethyl]amino}carbonyl)-5-methylhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pd/C / methanol / 3 h

2: 75 percent / NMM; TBTU / dimethylformamide / 2 h / 20 °C

With 4-methyl-morpholine; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm010127e