C₃₈H₆₅F₃O₆Si₂

Base Information

• Chemical Name: C₃₈H₆₅F₃O₆Si₂
• CAS No.: 1598429-63-0
• Molecular Formula: C₃₈H₆₅F₃O₆Si₂
• Molecular Weight: 731.097
• Mol file: 1598429-63-0.mol

Synonyms:C₃₈H₆₅F₃O₆Si₂

Chemical Property of C₃₈H₆₅F₃O₆Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₆₅F₃O₆Si₂

There total 8 articles about C₃₈H₆₅F₃O₆Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

C28H58O4Si2 (1598429-50-5) + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → C38H65F3O6Si2 (1598429-63-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201309386

Reference yield:

5-Hexen-1-ol (821-41-0) → C38H65F3O6Si2 (1598429-63-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: pyridinium chlorochromate / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: titanium tetrachloride / dichloromethane / 0.33 h / -50 °C / Inert atmosphere

2.2: 1 h / -50 - -40 °C / Inert atmosphere

2.3: 16 h / -78 - -50 °C / Inert atmosphere

3.1: trimethylaluminum / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

3.2: 16 h / -20 - 20 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

5.1: tetrahydrofuran; diethyl ether / 0.83 h / 0 - 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; (+)-diisopinocampheylborane trifluoromethanesulfonate / dichloromethane / 2 h / -78 - 0 °C / Inert atmosphere

6.2: 20 h / -78 - -20 °C / Inert atmosphere

7.1: triethylamine; dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; trimethylaluminum; titanium tetrachloride; (+)-diisopinocampheylborane trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 5.1: |Grignard Reaction;

DOI:10.1002/anie.201309386

Reference yield:

hex-5-en-1-al (764-59-0) → C38H65F3O6Si2 (1598429-63-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: titanium tetrachloride / dichloromethane / 0.33 h / -50 °C / Inert atmosphere

1.2: 1 h / -50 - -40 °C / Inert atmosphere

1.3: 16 h / -78 - -50 °C / Inert atmosphere

2.1: trimethylaluminum / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 16 h / -20 - 20 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

4.1: tetrahydrofuran; diethyl ether / 0.83 h / 0 - 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; (+)-diisopinocampheylborane trifluoromethanesulfonate / dichloromethane / 2 h / -78 - 0 °C / Inert atmosphere

5.2: 20 h / -78 - -20 °C / Inert atmosphere

6.1: triethylamine; dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; trimethylaluminum; titanium tetrachloride; (+)-diisopinocampheylborane trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 4.1: |Grignard Reaction;

DOI:10.1002/anie.201309386

upstream raw materials:

5-Hexen-1-ol

hex-5-en-1-al

(R)-3-hydroxy-1-((R)-4-isopropyl-2-thioxothiazolidin-3-yl)oct-7-en-1-one

C₁₀H₁₉NO₃