butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate

Base Information

• Chemical Name: butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate
• CAS No.: 1399317-16-8
• Molecular Formula: C₁₅H₂₂O₄S
• Molecular Weight: 298.403
• Mol file: 1399317-16-8.mol

Synonyms:butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate

Chemical Property of butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate

There total 2 articles about butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Benzyloxymethyl chloride (3587-60-8) + 1-butyl 3-chloro-1-propanesulfonate (146475-47-0) → butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate (1399317-16-8)

Guidance literature:

1-butyl 3-chloro-1-propanesulfonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃;

Benzyloxymethyl chloride; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 5h;

Reference yield:

Benzyloxymethyl chloride (3587-60-8) + 1-butyl cyclopropanesulfonate (83635-12-5) → butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate (1399317-16-8)

Guidance literature:

1-butyl cyclopropanesulfonate; With n-butyllithium; In tetrahydrofuran; at -78 - -75 ℃; for 0.25h;

Benzyloxymethyl chloride; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield: 91.0%

butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate (1399317-16-8) → 1-((benzyloxy)methyl)cyclopropane-1-sulfonyl chloride (1303510-68-0)

Guidance literature:

butyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate; With potassium thioacyanate; In 1,2-dimethoxyethane; water; at 23 ℃; for 15h; Reflux;

With thionyl chloride; In N,N-dimethyl-formamide; for 1.5h; Reflux;

DOI:10.1021/jm3008823

upstream raw materials:

Benzyloxymethyl chloride

1-butyl 3-chloro-1-propanesulfonate

1-butyl cyclopropanesulfonate

Downstream raw materials:

1-((benzyloxy)methyl)cyclopropane-1-sulfonyl chloride

1-(benzyloxymethyl)cyclopropanesulfonyl chloride

potassium 1-(benzyloxymethyl)-cyclopropanesulfonate