2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

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Chemical Name:2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one
CAS No.:944332-04-1
Molecular Formula:C₂₃H₁₈F₃N₃O₃
Molecular Weight:441.409
Hs Code.:

Synonyms:2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

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Chemical Property of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

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Technology Process of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

There total 9 articles about 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 944332-05-2
1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

: 944332-04-1
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

Guidance literature:: 1-benzyloxymethyl-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one; With hydrogenchloride; hydrogen; 5%-palladium/activated carbon; In ethanol; water; at 50 ℃; for 1h; under 760.051 Torr;

With ammonia; water; In methanol; for 1h;

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 944332-04-1
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C

2.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 3 h / 20 °C

3.1: dimethyl zinc(II) / toluene / 28.25 h / -40 - 20 °C

4.1: boron tribromide / dichloromethane / 0.5 h / -70 - 0 °C

5.1: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 80 °C

7.1: potassium phosphate / palladium diacetate; catacxium A / water; toluene / 2 h / 100 °C

8.1: hydrazine / ethylene glycol / 8.5 h / 60 - 130 °C

9.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 1 h / 50 °C / 760.05 Torr

9.2: 1 h

With hydrogenchloride; sodium hydroxide; potassium phosphate; hydrogen; dimethyl zinc(II); potassium acetate; boron tribromide; potassium carbonate; hydrazine; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5%-palladium/activated carbon; tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate; catacxium A; In 1,4-dioxane; ethanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; toluene; 7.1: Suzuki Coupling;

Reference yield:

: 944334-01-4
4-bromo-2-vinyloxy-1-methoxybenzene

: 944332-04-1
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-(2-fluorobenzyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: dimethyl zinc(II) / toluene / 28.25 h / -40 - 20 °C

2.1: boron tribromide / dichloromethane / 0.5 h / -70 - 0 °C

3.1: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 80 °C

5.1: potassium phosphate / palladium diacetate; catacxium A / water; toluene / 2 h / 100 °C

6.1: hydrazine / ethylene glycol / 8.5 h / 60 - 130 °C

7.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 1 h / 50 °C / 760.05 Torr

7.2: 1 h

With hydrogenchloride; sodium hydroxide; potassium phosphate; hydrogen; dimethyl zinc(II); potassium acetate; boron tribromide; hydrazine; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5%-palladium/activated carbon; tetrabutylammomium bromide; catacxium A; In 1,4-dioxane; ethanol; dichloromethane; water; ethylene glycol; toluene; 5.1: Suzuki Coupling;