Technology Process of C18H16N4O2
There total 7 articles about C18H16N4O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / tetrahydrofuran; water / 6 h / Inert atmosphere; Reflux
2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water;
1: |Suzuki Coupling;
DOI:10.1021/jm4000215
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 0.5h;
DOI:10.1021/jm4000215
- Guidance literature:
-
Multi-step reaction with 6 steps
1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C
2: acetic acid; sodium nitrite / 20 °C
3: iodine; potassium hydroxide / N,N-dimethyl-formamide / 3 h / 20 °C
4: dmap; triethylamine / acetonitrile / 0.83 h / 20 °C
5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / tetrahydrofuran; water / 6 h / Inert atmosphere; Reflux
6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
With
dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium 10% on activated carbon; hydrogen; iodine; sodium carbonate; acetic acid; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium nitrite;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
5: |Suzuki Coupling;
DOI:10.1021/jm4000215
