(4R,8R)-1-<(4-methoxyphenyl)diphenylmethoxy>-8-methy-10-(tetrahydropyranyloxy)-4-decanol

Base Information

• Chemical Name: (4R,8R)-1-<(4-methoxyphenyl)diphenylmethoxy>-8-methy-10-(tetrahydropyranyloxy)-4-decanol
• CAS No.: 89872-62-8
• Molecular Formula: C₃₆H₄₈O₅
• Molecular Weight: 560.774
• Mol file: 89872-62-8.mol

Synonyms:(4R,8R)-1-<(4-methoxyphenyl)diphenylmethoxy>-8-methy-10-(tetrahydropyranyloxy)-4-decanol

Chemical Property of (4R,8R)-1-<(4-methoxyphenyl)diphenylmethoxy>-8-methy-10-(tetrahydropyranyloxy)-4-decanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,8R)-1-<(4-methoxyphenyl)diphenylmethoxy>-8-methy-10-(tetrahydropyranyloxy)-4-decanol

There total 8 articles about (4R,8R)-1-<(4-methoxyphenyl)diphenylmethoxy>-8-methy-10-(tetrahydropyranyloxy)-4-decanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(3S)-5-bromo-3-methyl-1-(tetrahydropyranyloxy)pentane + (2S)-5<(4-methoxyphenyl) diphenylmethoxy>-1,2-epoxypentane (89872-59-3) → (4R,8R)-1-<(4-methoxyphenyl)diphenylmethoxy>-8-methy-10-(tetrahydropyranyloxy)-4-decanol (89872-62-8)

Guidance literature:

With copper(l) iodide; iodine; magnesium; In tetrahydrofuran; 1.) 5 min, 2.) reflux 30 min, , 10 min, in THF, 3.) 1 h, -30 deg C, 4 h, O deg C, 14 h, r.t.,;

DOI:10.1002/hlca.19840670132

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → (4R,8R)-1-<(4-methoxyphenyl)diphenylmethoxy>-8-methy-10-(tetrahydropyranyloxy)-4-decanol (89872-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / 20 h / 0 - 20 °C

2: 96 percent / 1.) Mg, I₂, 3.) CuI / tetrahydrofuran / 1.) 5 min, 2.) reflux 30 min, , 10 min, in THF, 3.) 1 h, -30 deg C, 4 h, O deg C, 14 h, r.t.,

With copper(l) iodide; iodine; magnesium; In tetrahydrofuran;

DOI:10.1002/hlca.19840670132

Reference yield:

(S)-5-tosyloxypentan-4-olide (58879-34-8) → (4R,8R)-1-<(4-methoxyphenyl)diphenylmethoxy>-8-methy-10-(tetrahydropyranyloxy)-4-decanol (89872-62-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 67 percent / LiBH₄ / tetrahydrofuran / 6 h / Ambient temperature

2: pyridine / 6 h / Ambient temperature

3: 8.6 g / Na, / methanol; diethyl ether / 0.25 h / 0 °C

4: 96 percent / 1.) Mg, I₂, 3.) CuI / tetrahydrofuran / 1.) 5 min, 2.) reflux 30 min, , 10 min, in THF, 3.) 1 h, -30 deg C, 4 h, O deg C, 14 h, r.t.,

With copper(l) iodide; lithium borohydride; iodine; sodium; magnesium; In tetrahydrofuran; pyridine; methanol; diethyl ether;

DOI:10.1002/hlca.19840670132

upstream raw materials:

(2S)-5<(4-methoxyphenyl) diphenylmethoxy>-1,2-epoxypentane

3,4-dihydro-2H-pyran

(S)-5-tosyloxypentan-4-olide

methyl 3-(R)-methyl-5-hydroxypentanoate