(trans) 4-{[(3-iodo-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl]amino}cyclohexanol

Base Information

Chemical Name:(trans) 4-{[(3-iodo-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl]amino}cyclohexanol
CAS No.:760993-23-5
Molecular Formula:C₁₈H₂₂IN₃O₂
Molecular Weight:439.296
Hs Code.:

Synonyms:(trans) 4-{[(3-iodo-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl]amino}cyclohexanol

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Chemical Property of (trans) 4-{[(3-iodo-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl]amino}cyclohexanol

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Technology Process of (trans) 4-{[(3-iodo-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl]amino}cyclohexanol

There total 7 articles about (trans) 4-{[(3-iodo-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl]amino}cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 760991-05-7
3-iodo-7-methoxy-1,4-dihydroindeno[1, 2-c]pyrazole-6-carbaldehyde

: 50910-54-8
trans-4-aminocyclohexanol hydrochloride

: 760993-23-5
(trans) 4-{[(3-iodo-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl]amino}cyclohexanol

Guidance literature:: 3-iodo-7-methoxy-1,4-dihydroindeno[1, 2-c]pyrazole-6-carbaldehyde; trans-4-aminocyclohexanol hydrochloride; With potassium carbonate; In ethanol; at 100 ℃; for 3h;

With sodium tetrahydroborate; at 20 ℃;

Reference yield:

: C₁₈H₂₀IN₃O₂

: 760993-23-5
(trans) 4-{[(3-iodo-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl]amino}cyclohexanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2007.04.055

Reference yield:

: 760991-02-4
7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole

: 760993-23-5
(trans) 4-{[(3-iodo-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl]amino}cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Br₂; AcOH

2: 99 percent / PhLi; s-BuLi / tetrahydrofuran / -78 - 20 °C

3: 68 percent / NIS / dimethylformamide / 80 °C

4: TsOH / toluene / Heating

5: NaBH₄ / ethanol; tetrahydrofuran

With sodium tetrahydroborate; N-iodo-succinimide; bromine; sec.-butyllithium; toluene-4-sulfonic acid; acetic acid; phenyllithium; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2007.04.055