ISOCHROMAN-4-ONE

Base Information

• Chemical Name: ISOCHROMAN-4-ONE
• CAS No.: 20924-56-5
• Molecular Formula: C9H8O2
• Molecular Weight: 148.161
• Hs Code.: 2932999099
• Mol file: 20924-56-5.mol

Synonyms:4-Isochromanone(7CI,8CI);1H-Isochromen-4(3H)-one;

Chemical Property of ISOCHROMAN-4-ONE

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Melting Point: 48 °C
• Refractive Index: 1.562
• Boiling Point: 279.501 °C at 760 mmHg
• Flash Point: 134.664 °C
• PSA: 26.30000
• Density: 1.197g/cm³
• LogP: 1.39950
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.9% ^*data from raw suppliers

Isochroman-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Isochroman-4-one is used as a reactant in the preparation of isochromanone hybrids bearing benzyl pyridinium moiety as dual binding site AChE inhibitors.

Technology Process of ISOCHROMAN-4-ONE

There total 1 articles about ISOCHROMAN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

isochromane (493-05-0) → isochroman-1-one (4702-34-5) + isochroman-4-one (20924-56-5)

Guidance literature:

With carbon monoxide; oxygen; copper dichloride; palladium dichloride; In tert-butyl alcohol; for 72h; under 45600 Torr;

DOI:10.1246/cl.1994.1149

Reference yield: 89.5%

isochroman-4-one (20924-56-5) → isochroman-4-amine (147663-00-1)

Guidance literature:

With ammonia; hydrogen; In ethanol; at 95 ℃; for 9h; under 3750.38 - 30003 Torr; Autoclave; Inert atmosphere;

Reference yield: 30.0%

isochroman-4-one (20924-56-5) + p-Chlorothiophenol (106-54-7) → C15H11ClO2S

Guidance literature:

With di-tert-butyl peroxide; at 120 ℃; for 6h;

DOI:10.1055/s-0034-1380125

upstream raw materials:

isochromane

Downstream raw materials:

isochroman-4-amine

Refernces

• 1、 Miyamoto, Masanori,Minami, Yumiko,Ukaji, Yutaka,Kinoshita, Hideki,Inomata, Katsuhiko. "A New Aerobic Oxidation System Using Pd-Cu Catalysts in the Presence of CO". . p. 1149 - 1152. Retrieved 2007/10/02.