2-((2-((5-butyl-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((2-((5-butyl-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1564256-25-2
Molecular Formula:C₂₇H₃₃ClN₆O
Molecular Weight:493.052
Hs Code.:

Synonyms:2-((2-((5-butyl-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((2-((5-butyl-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((2-((5-butyl-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

There total 8 articles about 2-((2-((5-butyl-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.8%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 1564256-66-1
C₁₅H₂₄N₂

: 1564256-25-2
2-((2-((5-butyl-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With (1S)-10-camphorsulfonic acid; In isopropyl alcohol; at 80 ℃; for 1h; Microwave irradiation;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-59-2
C₂₁H₂₅BrN₂O₂

: 1564256-25-2
2-((2-((5-butyl-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

2.1: potassium carbonate / 1,2-dichloro-ethane / 2 h / Reflux

3.1: methanol / Reflux

4.1: acetic acid / dichloromethane / 0.5 h

4.2: 1 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h

6.1: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; (1S)-10-camphorsulfonic acid; hydrogen; potassium carbonate; acetic acid; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1021/ml400373j

Reference yield:

: C₁₄H₁₈N₂O₂

: 1564256-25-2
2-((2-((5-butyl-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / dichloromethane / 0.5 h

1.2: 1 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h

3.1: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With palladium 10% on activated carbon; (1S)-10-camphorsulfonic acid; hydrogen; acetic acid; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml400373j