2-(3-Benzyl-8-methoxycarbonylmethylamino-2-methyl-indolizin-1-yl)-glyoxylamide

Base Information

• Chemical Name: 2-(3-Benzyl-8-methoxycarbonylmethylamino-2-methyl-indolizin-1-yl)-glyoxylamide
• CAS No.: 177559-99-8
• Molecular Formula: C₂₁H₂₁N₃O₄
• Molecular Weight: 379.415
• Mol file: 177559-99-8.mol

Synonyms:2-(3-Benzyl-8-methoxycarbonylmethylamino-2-methyl-indolizin-1-yl)-glyoxylamide

Chemical Property of 2-(3-Benzyl-8-methoxycarbonylmethylamino-2-methyl-indolizin-1-yl)-glyoxylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-Benzyl-8-methoxycarbonylmethylamino-2-methyl-indolizin-1-yl)-glyoxylamide

There total 6 articles about 2-(3-Benzyl-8-methoxycarbonylmethylamino-2-methyl-indolizin-1-yl)-glyoxylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(3-benzyl-8-(N-benzyloxycarbonyl-N-methoxycarbonylmethyl)amino-2-methyl-indolizin-1-yl)-glyoxylamide (177559-97-6) → 2-(3-Benzyl-8-methoxycarbonylmethylamino-2-methyl-indolizin-1-yl)-glyoxylamide (177559-99-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 3h;

DOI:10.1021/jm960395q

Reference yield:

2-methyl-3-pyridinamine (3430-10-2) → 2-(3-Benzyl-8-methoxycarbonylmethylamino-2-methyl-indolizin-1-yl)-glyoxylamide (177559-99-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 68 percent / dimethylformamide / 48 h

2: 90 percent / NaH / dimethylformamide / 2.5 h / Ambient temperature

3: 42 percent / NaHCO₃

4: tetrahydrofuran / 1 h / 0 °C

5: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

6: 78 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h

With ammonium hydroxide; hydrogen; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm960395q

Reference yield:

3-(N-benzyloxycarbonyl)-2-methylpyridine (177559-93-2) → 2-(3-Benzyl-8-methoxycarbonylmethylamino-2-methyl-indolizin-1-yl)-glyoxylamide (177559-99-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / NaH / dimethylformamide / 2.5 h / Ambient temperature

2: 42 percent / NaHCO₃

3: tetrahydrofuran / 1 h / 0 °C

4: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

5: 78 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h

With ammonium hydroxide; hydrogen; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm960395q

upstream raw materials:

2-(3-benzyl-8-(N-benzyloxycarbonyl-N-methoxycarbonylmethyl)amino-2-methyl-indolizin-1-yl)-glyoxylamide

2-methyl-3-pyridinamine

3-(N-benzyloxycarbonyl)-2-methylpyridine

3-(N-benzyloxycarbonyl-N-methoxycarbonylmethyl)amino-2-methylpyridine