methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Base Information

Chemical Name:methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate
CAS No.:1562995-73-6
Molecular Formula:C₂₅H₁₉ClF₄N₄O₄
Molecular Weight:550.897
Hs Code.:

Synonyms:methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Suppliers and Price of methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

There total 14 articles about methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562995-72-5
methyl 4-(6-amino-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

: 6482-24-2
2-Bromoethyl methyl ether

: 1562995-73-6
methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: methyl 4-(6-amino-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h;

2-Bromoethyl methyl ether; In N,N-dimethyl-formamide; for 12h;

Reference yield:

: 603122-84-5
[2-fluoro-4-(methoxycarbonyl)phenyl]boronic acid

: 1562995-73-6
methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 12 h / 90 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 12 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; diphenyl phosphoryl azide; sodium hydride; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: |Suzuki Coupling;

Reference yield:

: 911434-05-4
5-bromo-2-methyl-3-nitropyridine

: 1562995-73-6
methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: iron; ammonium chloride / water; ethanol / 0.67 h / 90 °C

2.1: triethylamine / dichloromethane / 36 h / 0 - 20 °C

3.1: potassium acetate; acetic acid; acetic anhydride / chloroform / 0.25 h / 20 °C

3.2: 48 h / 40 - 60 °C

4.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride; triethylamine / acetonitrile / 18 h / 100 °C / 15001.5 Torr

5.1: potassium hydroxide; iodine / N,N-dimethyl acetamide / 1 h

6.1: dmap; triethylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

7.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 20 °C

8.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 1 h / 100 °C / Microwave irradiation

9.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 12 h / 90 °C

10.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

10.2: 12 h

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; diphenyl phosphoryl azide; water; iodine; potassium acetate; acetic anhydride; iron; sodium hydride; sodium carbonate; ammonium chloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; triethylamine; potassium hydroxide; palladium dichloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 8.1: |Suzuki Coupling;