2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Base Information

Chemical Name:2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt
CAS No.:1283143-05-4
Molecular Formula:C₂HF₃O₂*C₂₆H₂₆FNO₄
Molecular Weight:549.519
Hs Code.:

Synonyms:2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

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Chemical Property of 2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

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Technology Process of 2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

There total 9 articles about 2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.2%

: 1283146-67-7
2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile

: 76-05-1
trifluoroacetic acid

: 1283143-05-4
2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: 2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile; With water; potassium hydroxide; In ethanol; at 120 ℃; for 1.5h;

trifluoroacetic acid; In water;

Reference yield:

: 55289-36-6
3-bromo-2-methylaniline

: 1283143-05-4
2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid; sodium nitrite / water / 0 - 100 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3: zinc / acetic acid / 20 °C / Inert atmosphere

4: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 20 °C

5: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

6: triethylamine / dichloromethane / 1 h / 0 °C

7: dimethyl sulfoxide / 50 °C

8: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / N,N-dimethyl-formamide / 1.67 h / 100 °C / Inert atmosphere; Sealed tube

9: potassium hydroxide / water; ethanol / 2 h / 120 °C / Sealed tube

With potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; caesium carbonate; toluene-4-sulfonic acid; triethylamine; potassium iodide; potassium hydroxide; sodium hydroxide; zinc; sodium nitrite; In ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 1283146-61-1
1-bromo-2-methyl-3-(4-nitrophenoxy)benzene

: 1283143-05-4
2-((2S)-1-(4-(2'-fluoro-5'-methoxy-2-methylbiphenyl-3-yloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 7 steps

1: zinc / acetic acid / 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 20 °C

3: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

4: triethylamine / dichloromethane / 1 h / 0 °C

5: dimethyl sulfoxide / 50 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / N,N-dimethyl-formamide / 1.67 h / 100 °C / Inert atmosphere; Sealed tube

7: potassium hydroxide / water; ethanol / 2 h / 120 °C / Sealed tube

With potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; triethylamine; potassium iodide; potassium hydroxide; sodium hydroxide; zinc; sodium nitrite; In ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01559