C₅₅H₆₁N₃O₈

Base Information

• Chemical Name: C₅₅H₆₁N₃O₈
• CAS No.: 1257063-26-5
• Molecular Formula: C₅₅H₆₁N₃O₈
• Molecular Weight: 892.105
• Mol file: 1257063-26-5.mol

Synonyms:C₅₅H₆₁N₃O₈

Chemical Property of C₅₅H₆₁N₃O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₅H₆₁N₃O₈

There total 9 articles about C₅₅H₆₁N₃O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C23H23NO4 (1257063-25-4) + (2S,4R)-1-(6-aminohexanoyl)-4-hydroxy-2-(4,4′-dimethoxytrityloxymethyl)pyrrolidine (851912-61-3) → C55H61N3O8 (1257063-26-5)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ol102205j

Reference yield:

5,6,11,12-tetrahydro-5,11-epoxydibenzocyclooctene (77733-39-2,66365-45-5) → C55H61N3O8 (1257063-26-5)

Guidance literature:

Multi-step reaction with 8 steps

1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice; Inert atmosphere

3: bromine / chloroform / 0.67 h / 0 - 4 °C / Cooling with ice

4: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 20 °C

5: triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 20 °C

7: lithium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With 1H-imidazole; n-butyllithium; water; bromine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

3-hydroxy-1,2:5,6-dibenzocycloocta-1,5,7-triene (1144-71-4) → C55H61N3O8 (1257063-26-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice; Inert atmosphere

2: bromine / chloroform / 0.67 h / 0 - 4 °C / Cooling with ice

3: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 20 °C

4: triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

5: triethylamine / dichloromethane / 20 °C

6: lithium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With 1H-imidazole; water; bromine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

upstream raw materials:

C₂₃H₂₃NO₄

(2S,4R)-1-(6-aminohexanoyl)-4-hydroxy-2-(4,4′-dimethoxytrityloxymethyl)pyrrolidine

phenylacetaldehyde

5,6,11,12-tetrahydro-5,11-epoxydibenzocyclooctene

Downstream raw materials:

C₅₉H₆₅N₃O₁₁

C₆₄H₇₈N₅O₉P