(4S)-3-[1-(3,5-difluorobenzyl)-3-methyl-3-pyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Name:(4S)-3-[1-(3,5-difluorobenzyl)-3-methyl-3-pyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:1404062-99-2
Molecular Formula:C₂₈H₂₉F₂N₃O₆
Molecular Weight:541.552
Hs Code.:

Synonyms:(4S)-3-[1-(3,5-difluorobenzyl)-3-methyl-3-pyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of (4S)-3-[1-(3,5-difluorobenzyl)-3-methyl-3-pyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of (4S)-3-[1-(3,5-difluorobenzyl)-3-methyl-3-pyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about (4S)-3-[1-(3,5-difluorobenzyl)-3-methyl-3-pyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.6%

: 1404063-69-9
1-(3,5-difluorobenzyl)-3-methylpyrrolidin-3-ol

: 76093-33-9
(R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

: 1404062-99-2
(4S)-3-[1-(3,5-difluorobenzyl)-3-methyl-3-pyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: (R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 25 ℃; Cooling with ice;

1-(3,5-difluorobenzyl)-3-methylpyrrolidin-3-ol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; Cooling with ice;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1404062-99-2
(4S)-3-[1-(3,5-difluorobenzyl)-3-methyl-3-pyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium bicarbonate / ethanol; water / 55 - 60 °C / Reflux

2.1: methanol; water; sodium hydroxide / 6 h / 70 °C

3.1: quinindine / methanol / 3 h / 90 °C / Reflux

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 25 °C

4.2: 25 °C / Cooling with ice

With methanol; oxalyl dichloride; water; quinindine; ammonium bicarbonate; sodium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 74936-72-4
5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

: 1404062-99-2
(4S)-3-[1-(3,5-difluorobenzyl)-3-methyl-3-pyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: quinindine / methanol / 3 h / 90 °C / Reflux

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 25 °C

2.2: 25 °C / Cooling with ice

With oxalyl dichloride; quinindine; In methanol; dichloromethane; N,N-dimethyl-formamide;