trans-1-(p-chlorophenyl-)-2-azido-3-(p-tolyl-)-2-propene-1-one

Base Information

• Chemical Name: trans-1-(p-chlorophenyl-)-2-azido-3-(p-tolyl-)-2-propene-1-one
• CAS No.: 76075-53-1
• Molecular Formula: C₁₆H₁₂ClN₃O
• Molecular Weight: 297.744
• Mol file: 76075-53-1.mol

Synonyms:trans-1-(p-chlorophenyl-)-2-azido-3-(p-tolyl-)-2-propene-1-one

Chemical Property of trans-1-(p-chlorophenyl-)-2-azido-3-(p-tolyl-)-2-propene-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1-(p-chlorophenyl-)-2-azido-3-(p-tolyl-)-2-propene-1-one

There total 2 articles about trans-1-(p-chlorophenyl-)-2-azido-3-(p-tolyl-)-2-propene-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-azido-4'-chloroacetophenone (26086-60-2) + 4-methyl-benzaldehyde (104-87-0) → trans-1-(p-chlorophenyl-)-2-azido-3-(p-tolyl-)-2-propene-1-one (76075-53-1)

Guidance literature:

at 25 ℃;

Reference yield: 75.0%

1-(4-chlorophenyl)-3-(4-methylphenyl)prop-2-en-1-one (19672-63-0) → trans-1-(p-chlorophenyl-)-2-azido-3-(p-tolyl-)-2-propene-1-one (76075-53-1)

Guidance literature:

With sodium azide; ammonium cerium (IV) nitrate; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.11.065

Reference yield: 90.0%

trans-1-(p-chlorophenyl-)-2-azido-3-(p-tolyl-)-2-propene-1-one (76075-53-1) + triphenylphosphine (603-35-0) → 1-(4-chlorophenyl)-3-(p-tolyl)-2-((triphenylphosphoranylidene)amino)prop-2-en-1-one (344426-62-6)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1021/jo202588j

upstream raw materials:

2-azido-4'-chloroacetophenone

4-methyl-benzaldehyde

1-(4-chlorophenyl)-3-(4-methylphenyl)prop-2-en-1-one

Downstream raw materials:

Z-1-(4-chlorophenyl-)-2-amino-3-(4-tolyl-)-propene-2-one-1

E-1-(4-chlorophenyl-)-2-acetamido-3-(4-tolyl-)-propene-2-one-1

Z-1-(4-chlorophenyl-)-2-acetamido-3-(4-tolyl-)-propene-2-one-1

1-(4-chlorophenyl-)-3-(4-tolyl-)-propane-2-one-1