2-(4-bromophenyl)-8-(4-fluorobenzyl)-4-(4-flu orophenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine

Base Information

• Chemical Name: 2-(4-bromophenyl)-8-(4-fluorobenzyl)-4-(4-flu orophenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine
• CAS No.: 1360596-07-1
• Molecular Formula: C₂₆H₁₉BrF₂N₂S
• Molecular Weight: 509.417
• Mol file: 1360596-07-1.mol

Synonyms:2-(4-bromophenyl)-8-(4-fluorobenzyl)-4-(4-flu orophenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine

Chemical Property of 2-(4-bromophenyl)-8-(4-fluorobenzyl)-4-(4-flu orophenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(4-bromophenyl)-8-(4-fluorobenzyl)-4-(4-flu orophenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine

There total 1 articles about 2-(4-bromophenyl)-8-(4-fluorobenzyl)-4-(4-flu orophenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Tetrahydrothiopyran-4-one (1072-72-6) + 4-bromobenzamidine (22265-36-7) + 4-fluorobenzaldehyde (459-57-4) → 2-(4-bromophenyl)-8-(4-fluorobenzyl)-4-(4-flu orophenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine (1360596-07-1)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 140 ℃; for 0.283333h; regiospecific reaction; Microwave irradiation;

DOI:10.1016/j.tetlet.2011.12.128

upstream raw materials:

Tetrahydrothiopyran-4-one

4-bromobenzamidine

4-fluorobenzaldehyde