[2-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-4,5-dimethoxy-phenyl]-acetic acid ethyl ester

Base Information

Chemical Name:[2-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-4,5-dimethoxy-phenyl]-acetic acid ethyl ester
CAS No.:103225-56-5
Molecular Formula:C₁₉H₂₂O₈
Molecular Weight:378.379
Hs Code.:

Synonyms:[2-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-4,5-dimethoxy-phenyl]-acetic acid ethyl ester

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Chemical Property of [2-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-4,5-dimethoxy-phenyl]-acetic acid ethyl ester

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Technology Process of [2-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-4,5-dimethoxy-phenyl]-acetic acid ethyl ester

There total 2 articles about [2-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-4,5-dimethoxy-phenyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2033-24-1
cycl-isopropylidene malonate

: 103225-55-4
ethyl 2-(2-formyl-4,5-dimethoxyphenyl)acetate

: 103225-56-5
[2-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-4,5-dimethoxy-phenyl]-acetic acid ethyl ester

Guidance literature:: With piperidine; acetic acid; In benzene; for 3h; Heating;
DOI:10.1021/jo00367a017

Reference yield:

: 73053-80-2
ethyl 2-(bromomethyl)-4,5-dimethoxyphenylacetate

: 103225-56-5
[2-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-4,5-dimethoxy-phenyl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / (Bu₄N)2Cr₂O₇ / CHCl₃ / 2 h / Heating

2: 92 percent / piperidine, glacial acetic acid / benzene / 3 h / Heating

With piperidine; (Bu₄N)2Cr₂O₇; acetic acid; In chloroform; benzene;
DOI:10.1021/jo00367a017

Reference yield:

: 103225-56-5
[2-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-4,5-dimethoxy-phenyl]-acetic acid ethyl ester

: 103225-60-1
(1R,2S,4R,5R,8S)-8-Ethoxycarbonylmethyl-2-(2-ethoxycarbonylmethyl-4,5-dimethoxy-phenyl)-4-hydroxy-5-methyl-7-oxo-6-oxa-bicyclo[3.2.1]octane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 72 h / Heating

2: 1.) MCPBA, 2.) 3N aq. HClO₄ / 1.) CH₂Cl₂, from o deg C to RT, 2 h, 2.) THF, RT, 12 h

With perchloric acid; 3-chloro-benzenecarboperoxoic acid; In toluene;
DOI:10.1021/jo00367a017