(S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide

Base Information

• Chemical Name: (S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide
• CAS No.: 1207760-42-6
• Molecular Formula: C₂₁H₁₉ClN₆O₃
• Molecular Weight: 438.873

Synonyms:(S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide

Chemical Property of (S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide

Chemical Property:

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Technology Process of (S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide

There total 2 articles about (S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide (1207760-38-0) → (R)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide (1207760-41-5) + (S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide (1207760-42-6)

Guidance literature:

With Chiralpak AD; In n-heptane; isopropyl alcohol; at 40 ℃; Resolution of racemate;

Reference yield:

4-chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine (852313-98-5) + (S)-2-hydroxy-3-methoxy-N-(5-methylpyridin-2-yl)propanamide (1207831-43-3) → (S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide (1207760-42-6)

Guidance literature:

(S)-2-hydroxy-3-methoxy-N-(5-methylpyridin-2-yl)propanamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.216667h; Inert atmosphere;

4-chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine; In tetrahydrofuran; at 50 ℃;

Reference yield: 20.7%

(S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide (1207760-42-6) → (S)-3-methoxy-N-(5-methylpyridin-2-yl)-2-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)propanamide (1207826-85-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 24h;

upstream raw materials:

4-chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine

(S)-2-hydroxy-3-methoxy-N-(5-methylpyridin-2-yl)propanamide

2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-3-methoxy-N-(5-methylpyridin-2-yl)propanamide

Downstream raw materials:

(S)-3-methoxy-N-(5-methylpyridin-2-yl)-2-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)propanamide

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