N-benzyl-2-aza-6-(3-(ethoxycarbonyl)propylidene)bicyclo<2.2.2>octane

Base Information

• Chemical Name: N-benzyl-2-aza-6-(3-(ethoxycarbonyl)propylidene)bicyclo<2.2.2>octane
• CAS No.: 127310-07-0
• Molecular Formula: C₂₀H₂₇NO₂
• Molecular Weight: 313.44
• Mol file: 127310-07-0.mol

Synonyms:N-benzyl-2-aza-6-(3-(ethoxycarbonyl)propylidene)bicyclo<2.2.2>octane

Chemical Property of N-benzyl-2-aza-6-(3-(ethoxycarbonyl)propylidene)bicyclo<2.2.2>octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-benzyl-2-aza-6-(3-(ethoxycarbonyl)propylidene)bicyclo<2.2.2>octane

There total 2 articles about N-benzyl-2-aza-6-(3-(ethoxycarbonyl)propylidene)bicyclo<2.2.2>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 4-bromobutyrate (2969-81-5) → N-benzyl-2-aza-6-(3-(ethoxycarbonyl)propylidene)bicyclo<2.2.2>octane (127310-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 51 h / Heating

2: 1.) sodium hydride / 1.) DMF, 10 deg C, 40 min, 2.) a) 10 deg C, 4 h, b) RT, 14 h

With sodium hydride; In benzene;

DOI:10.1021/ja00167a054

Reference yield:

N-benzyl-2-azabicyclo<2.2.2>octan-6-one (41959-26-6,63169-69-7) + (3-ethoxycarbonylpropyl)triphenylphosphonium bromide (50479-11-3) → N-benzyl-2-aza-6-(3-(ethoxycarbonyl)propylidene)bicyclo<2.2.2>octane (127310-07-0)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 10 deg C, 40 min, 2.) a) 10 deg C, 4 h, b) RT, 14 h;

DOI:10.1021/ja00167a054

Reference yield:

N-benzyl-2-aza-6-(3-(ethoxycarbonyl)propylidene)bicyclo<2.2.2>octane (127310-07-0) → C31H45NO2 (127310-11-6,127419-13-0)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / acetic acid / 62 h / 72 °C / 2280 Torr

2: 6 N HCl / 48 h / 110 °C

3: Bio-Rad AG₃ * 4A (hydroxide form) / H₂O

4: ethanol; tetrahydrofuran / Irradiation

With hydrogenchloride; Bio-Rad AG₃ * 4A (hydroxide form); hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; acetic acid;

DOI:10.1021/ja00167a054

upstream raw materials:

N-benzyl-2-azabicyclo<2.2.2>octan-6-one

(3-ethoxycarbonylpropyl)triphenylphosphonium bromide

Ethyl 4-bromobutyrate

Downstream raw materials:

C₃₁H₄₅NO₂

C₃₁H₄₅NO₂