(R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate

Base Information

Chemical Name:(R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate
CAS No.:1429384-05-3
Molecular Formula:C₂₂H₂₄BrCl₂NO₄
Molecular Weight:517.247
Hs Code.:

Synonyms:(R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate

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Chemical Property of (R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate

Chemical Property:

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Technology Process of (R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate

There total 1 articles about (R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₃Cl₂NO

: (R)-2-bromo-4-tert-butoxy-4-oxobutanoic acid

: 1429384-05-3
(R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate

Guidance literature:: (R)-2-bromo-4-tert-butoxy-4-oxobutanoic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 1h;

C₁₄H₁₃Cl₂NO; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield:

: 1429384-05-3
(R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate

: 1429384-06-4
tert-butyl 2-((2S,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetate

: 1429384-07-5
tert-butyl 2-((2R,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl)acetate

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

Reference yield:

: 1429384-05-3
(R)-tert-butyl 3-bromo-4-((1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylamino)-4-oxobutanoate

: 1429385-31-8
2-((2R,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((S)-1-hydroxybutan-2-yl)-3-oxomorpholin-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2: sodium t-butanolate / 1,4-dioxane / 85 °C

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 2 h / 0 °C

4: trifluoroacetic acid / water; dichloromethane; acetonitrile / 0.5 h / 25 °C

With water; sodium hydride; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;