2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Base Information

• Chemical Name: 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
• CAS No.: 126069-70-3
• Molecular Formula: C7H8F3N3
• Molecular Weight: 191.156
• Hs Code.: 2933990090
• European Community (EC) Number: 842-575-8
• DSSTox Substance ID: DTXSID30563350
• Wikidata: Q72512925
• Mol file: 126069-70-3.mol

Synonyms:126069-70-3;2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine;2-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine;MFCD09834983;IMIDAZO[1,2-A]PYRAZINE, 5,6,7,8-TETRAHYDRO-2-(TRIFLUOROMETHYL)-;2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo-[1,2-a]pyrazine;SCHEMBL108034;DTXSID30563350;AKOS005255469;Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI);AB53003;FS-2796;SY032917;AM20080198;CS-0018906;EN300-1697072;A805474;5,6,7,8-Tetrahydro-2-(trifluoromethyl)imidazo[1,2-a]pyrazine;2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-alpha]pyrazine;2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1.2-alpha]pyrazine

Chemical Property of 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Chemical Property:

• Vapor Pressure: 0.000511mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 312.986 °C at 760 mmHg
• PKA: 7.90±0.20(Predicted)
• Flash Point: 143.089 °C
• PSA: 29.85000
• Density: 1.56 g/cm³
• LogP: 1.33390
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 191.06703175
• Heavy Atom Count: 13
• Complexity: 194

Purity/Quality:

97% ^*data from raw suppliers

2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN2C=C(N=C2CN1)C(F)(F)F
• Uses: 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine is used to study fused heterocycle-linked triazole derivatives.

Technology Process of 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

There total 1 articles about 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

2-trifluoromethylimidazo<1,2-a>pyrazine (109113-96-4) → 2-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,2-a]pyrazine (126069-70-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 12h;

Reference yield: 98.0%

2-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,2-a]pyrazine (126069-70-3) + 2,4-dichlorobenzoyl chloride (89-75-8) → 7-[(2,4-dichlorophenyl)carbonyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1253800-46-2)

Guidance literature:

With diethylaminomethyl polystyrene; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 42.1%

2-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,2-a]pyrazine (126069-70-3) + 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole (124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2) → (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-(2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)butan-2-ol (1575607-72-5)

Guidance literature:

In acetonitrile; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm4016284

upstream raw materials:

2-trifluoromethylimidazo<1,2-a>pyrazine

Downstream raw materials:

C₂₇H₂₉F₆N₇O₂

C₂₀H₁₆ClF₃N₆O₂

7-[(2,4-dichlorophenyl)carbonyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

7-[(2-chloro-4-fluorophenyl)carbonyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine