5-[4-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-but-(Z)-ylidene]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

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Chemical Name:5-[4-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-but-(Z)-ylidene]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester
CAS No.:171017-31-5
Molecular Formula:C₂₆H₃₄N₂O₆
Molecular Weight:470.566
Hs Code.:

Synonyms:5-[4-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-but-(Z)-ylidene]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

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Chemical Property of 5-[4-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-but-(Z)-ylidene]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

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Technology Process of 5-[4-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-but-(Z)-ylidene]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

There total 13 articles about 5-[4-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-but-(Z)-ylidene]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 171017-17-7
N-benzyl-N-tert-butoxycarbonyl-4-oxo-butanamide

: 181635-62-1
(1-tert-butoxycarbonyl-3-methyl-3-pyrrolin)-5-yl-phosphonic acid diethyl ester

: 171017-31-5
5-[4-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-but-(Z)-ylidene]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4020(98)00746-7

Reference yield: 90.0%

: (R)-5-[(R)-1-Acetoxy-4-(benzyl-tert-butoxycarbonyl-amino)-4-oxo-butyl]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 171017-31-5
5-[4-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-but-(Z)-ylidene]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene; for 5h; Ambient temperature;
DOI:10.1016/0040-4039(95)01568-3

Reference yield:

: 58170-50-6
pent-4-enoic acid benzylamide

: 171017-31-5
5-[4-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-but-(Z)-ylidene]-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Et₃N, DMAP / tetrahydrofuran / 3 h / Ambient temperature

2: 1.) ozone, 2.) Me₂S / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, room temp., 15 h

3: 95 percent / NaH / tetrahydrofuran / Ambient temperature

With dmap; dimethylsulfide; sodium hydride; ozone; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(98)00746-7