Technology Process of (1R)-1-(2,5-dimethoxyphenyl)-2-nitroethanol
There total 4 articles about (1R)-1-(2,5-dimethoxyphenyl)-2-nitroethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,5-dimethoxybenzaldehyde;
With
2'',2''-bis-{4',5'-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranosido)-[2',1'-d]-oxazolin-2'-yl}-propan; copper(II) acetate monohydrate;
In
ethanol;
at 20 ℃;
for 0.333333h;
nitromethane;
In
ethanol;
at 10 ℃;
for 40h;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1016/j.tetasy.2011.06.012
- Guidance literature:
-
With
hydroxynitrile lyase from Arabidopsis thaliana;
In
aq. phosphate buffer; (2)H8-toluene;
at 30 ℃;
for 3h;
enantioselective reaction;
Resolution of racemate;
Enzymatic reaction;
DOI:10.1002/cbic.201800416
- Guidance literature:
-
With
copper(II) acetate dihydrate; (S)-1-{[(1-hydroxy-1,3,3-triphenylpropan-2-yl)imino]methyl}naphthalen-2-ol;
In
butan-1-ol;
at 20 ℃;
for 3h;
Overall yield = 83 %; enantioselective reaction;
DOI:10.1134/S1070428013060080
