O-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenylcarbamothioate

Base Information

Chemical Name:O-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenylcarbamothioate
CAS No.:1265174-89-7
Molecular Formula:C₂₄H₁₇F₆N₅O₂S
Molecular Weight:553.488
Hs Code.:

Synonyms:O-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenylcarbamothioate

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Chemical Property of O-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenylcarbamothioate

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Technology Process of O-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenylcarbamothioate

There total 5 articles about O-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenylcarbamothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228631-54-6
1-(6-(trifluoromethyl)pyridin-3-yl)ethanol

: 1265176-52-0
3-(4-Isothiocyanatophenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole

: 1265174-89-7
O-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenylcarbamothioate

Guidance literature:: 1-(6-(trifluoromethyl)pyridin-3-yl)ethanol; With sodium hydride; In tetrahydrofuran; toluene; mineral oil; at 0 - 20 ℃; for 0.25h;

3-(4-Isothiocyanatophenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole; In tetrahydrofuran; toluene; mineral oil; at 20 ℃; for 0.333333h;

Reference yield:

: 1181214-76-5
3-(4-nitrophenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole

: 1265174-89-7
O-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenylcarbamothioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium on activated charcoal / ethanol

2.1: potassium carbonate / dichloromethane / 0.17 h / Inert atmosphere; Cooling with ice

2.2: 0.5 h / Cooling with ice

3.1: sodium hydride / toluene; tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

3.2: 0.33 h / 20 °C

With hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; toluene; mineral oil;

Reference yield:

: C₁₄H₉BrF₃N₃O₃

: 1265174-89-7
O-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenylcarbamothioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol / 2 h / Reflux

2.1: hydrogen / palladium on activated charcoal / ethanol

3.1: potassium carbonate / dichloromethane / 0.17 h / Inert atmosphere; Cooling with ice

3.2: 0.5 h / Cooling with ice

4.1: sodium hydride / toluene; tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

4.2: 0.33 h / 20 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; toluene; mineral oil;