(R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid

Base Information

• Chemical Name: (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid
• CAS No.: 335595-52-3
• Molecular Formula: C₁₀H₁₁FO₃S
• Molecular Weight: 230.26
• Mol file: 335595-52-3.mol

Synonyms:(R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid

Chemical Property of (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid

There total 4 articles about (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.9%

4-Fluorothiophenol (371-42-6) + (S)-2-[(4-methoxybenzyloxy)carbonyl]-2-hydroxypropyl methanesulfonate → (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid (335595-52-3)

Guidance literature:

4-Fluorothiophenol; (S)-2-[(4-methoxybenzyloxy)carbonyl]-2-hydroxypropyl methanesulfonate; With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 5h;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield: 80.0%

4-Fluorothiophenol (371-42-6) + (5R)-5-(bromomethyl)-5-methyl-2-(tribromomethyl)-1,3-dioxolane-4-one → (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid (335595-52-3)

Guidance literature:

With sodium hydroxide; In water; isopropyl alcohol;

DOI:10.1016/S0040-4020(02)00560-4

Reference yield: 65.0%

4-Fluorothiophenol (371-42-6) → (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid (335595-52-3)

Guidance literature:

C₇H₈Br₄O₃; With sodium hydroxide; In water; isopropyl alcohol; at 20 ℃; for 3h;

4-Fluorothiophenol; In water; isopropyl alcohol;

With hydrogenchloride; In water;

upstream raw materials:

4-Fluorothiophenol

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

Downstream raw materials:

C₁₀H₁₁FO₅S

bicalutamide

(R)-bicalutamide