benzyl 2-(2-(2-methyl-6-oxohept-2-en-4-yl)-1H-indol-3-yl)ethylcarbamate

Base Information

Chemical Name:benzyl 2-(2-(2-methyl-6-oxohept-2-en-4-yl)-1H-indol-3-yl)ethylcarbamate
CAS No.:1330579-19-5
Molecular Formula:C₂₆H₃₀N₂O₃
Molecular Weight:418.536
Hs Code.:

Synonyms:benzyl 2-(2-(2-methyl-6-oxohept-2-en-4-yl)-1H-indol-3-yl)ethylcarbamate

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Chemical Property of benzyl 2-(2-(2-methyl-6-oxohept-2-en-4-yl)-1H-indol-3-yl)ethylcarbamate

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Technology Process of benzyl 2-(2-(2-methyl-6-oxohept-2-en-4-yl)-1H-indol-3-yl)ethylcarbamate

There total 3 articles about benzyl 2-(2-(2-methyl-6-oxohept-2-en-4-yl)-1H-indol-3-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 14559-88-7
2,2-dimethylethenylboronic acid

: 1330579-56-0
benzyl (E)-(2-(2-(3-oxobut-1-en-1-yl)-1H-indol-3-yl)ethyl)carbamate

: 1330579-19-5
benzyl 2-(2-(2-methyl-6-oxohept-2-en-4-yl)-1H-indol-3-yl)ethylcarbamate

Guidance literature:: With magnesium 2-methylpropan-2-olate; (R)-3,3'-diiodo-2,2'-dihydroxy-1,1'-binaphthyl; In 1,2-dichloro-ethane; at 70 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1021/ol2020847

Reference yield:

: 1330579-57-1
C₂₂H₂₂N₂O₃

: 1330579-19-5
benzyl 2-(2-(2-methyl-6-oxohept-2-en-4-yl)-1H-indol-3-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 0 - 20 °C

2: magnesium 2-methylpropan-2-olate; (R)-3,3'-diiodo-2,2'-dihydroxy-1,1'-binaphthyl / 1,2-dichloro-ethane / 48 h / 70 °C / Molecular sieve; Inert atmosphere

With magnesium 2-methylpropan-2-olate; sodium hydride; (R)-3,3'-diiodo-2,2'-dihydroxy-1,1'-binaphthyl; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol2020847

Reference yield:

: benzyl (2-(2-formyl-1H-indol-3-yl)ethyl)carbamate

: 1330579-19-5
benzyl 2-(2-(2-methyl-6-oxohept-2-en-4-yl)-1H-indol-3-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 10 h / Reflux

2: magnesium 2-methylpropan-2-olate; (1R,3'r)-3,3'-bis(perfluorophenyl)[1,1'-binaphthalene]-2,2'-diol / toluene / 70 - 78 °C / Molecular sieve; Inert atmosphere

With (1R,3'r)-3,3'-bis(perfluorophenyl)[1,1'-binaphthalene]-2,2'-diol; magnesium 2-methylpropan-2-olate; In toluene;
DOI:10.3390/molecules26061615