(1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester

Base Information

Chemical Name:(1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester
CAS No.:1026173-73-8
Molecular Formula:C₃₉H₄₁ClN₂O₄
Molecular Weight:637.219
Hs Code.:

Synonyms:(1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester

Suppliers and Price of (1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester

There total 2 articles about (1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-22-1
methyl chloroformate

: 1026151-76-7
(1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid benzyl ester

: 1026173-73-8
(1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm000960w

Reference yield:

: 18220-83-2
adamantan-1-ylacetaldehyde

: 1026173-73-8
(1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂ / 23 h / 20 °C

2: Et₃N; DMAP / CH₂Cl₂ / 2 h / 20 °C

With dmap; triethylamine; trifluoroacetic acid; In dichloromethane; 1: Pictet-Spengler reaction / 2: Acylation;
DOI:10.1021/jm000960w

Reference yield:

: 1026173-73-8
(1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester

: 1028270-18-9
(3R,5S)-3-Adamantan-1-ylmethyl-1-(2-chloro-benzyl)-2,7-dioxo-1,2,3,5,6,7-hexahydro-benzo[e][1,4]diazonine-4,5-dicarboxylic acid 5-benzyl ester 4-methyl ester

Guidance literature:: (1R,3S)-1-Adamantan-1-ylmethyl-9-(2-chloro-benzyl)-1,3,4,9-tetrahydro-β-carboline-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester; With ozone; In methanol; at -78 ℃;

With dimethylsulfide; In methanol; at 20 ℃; for 2h; Further stages.;
DOI:10.1021/jm000960w