Technology Process of 2-azetidin-3-yl-3-phenylquinoline hydrochloride
There total 3 articles about 2-azetidin-3-yl-3-phenylquinoline hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
methanol;
at 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: chloro-trimethyl-silane; zinc; ethylene dibromide / dimethyl amine / 1 h / 20 °C / Inert atmosphere
1.2: 16 h / 80 °C / Inert atmosphere
2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 12 h / 80 °C / Inert atmosphere
3.1: hydrogenchloride / methanol / 0.5 h / 20 °C
With
hydrogenchloride; chloro-trimethyl-silane; sodium carbonate; ethylene dibromide; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; methanol; water; dimethyl amine;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 12 h / 80 °C / Inert atmosphere
2: hydrogenchloride / methanol / 0.5 h / 20 °C
With
hydrogenchloride; sodium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; methanol; water;
