2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid

Base Information

Chemical Name:2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid
CAS No.:1255653-11-2
Molecular Formula:C₂₇H₃₀N₆O₂
Molecular Weight:470.574
Hs Code.:

Synonyms:2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid

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Chemical Property of 2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid

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Technology Process of 2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid

There total 9 articles about 2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1255652-71-1
2-(6-(benzylamino)-2-((tert-butoxycarbonyl)(4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid

: 1255653-11-2
2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ml100224d

Reference yield:

: 1236151-75-9
ethyl 2-(2-((tert-butoxycarbonyl)amino)-6-chloro-9H-purin-9-yl)acetate

: 1255653-11-2
2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 135 °C / Microwave irradiation; Sealed tube

3: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With di-isopropyl azodicarboxylate; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1: Mitsunobu reaction;
DOI:10.1021/ml100224d

Reference yield:

: 1255652-18-6
ethyl 2-(2-((tert-butoxycarbonyl)(4-cyclohexylbenzyl)amino)-6-chloro-9H-purin-9-yl)acetate

: 1255653-11-2
2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9H-purin-9-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 135 °C / Microwave irradiation; Sealed tube

2: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ml100224d