rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-thione

Base Information

Chemical Name:rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-thione
CAS No.:131637-57-5
Molecular Formula:C₁₅H₁₁FINOS
Molecular Weight:399.227
Hs Code.:

Synonyms:rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-thione

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Technology Process of rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-thione

There total 1 articles about rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 131637-56-4
rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-one

: 131637-57-5
rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-thione

Guidance literature:: With tetraphosphorus decasulfide; In diethylene glycol dimethyl ether; at 70 - 80 ℃; for 2.5h;
DOI:10.1021/jm00107a048

Reference yield:

: 131637-57-5
rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-thione

: [5-(2-Fluoro-phenyl)-7-iodo-3,5-dihydro-benzo[e][1,4]oxazepin-2-yl]-hydrazine

Guidance literature:: With hydrazine; In tetrahydrofuran; for 0.25h; Ambient temperature;
DOI:10.1021/jm00107a048

Reference yield:

: 131637-57-5
rac-5-(2-fluorophenyl)-1,5-dihydro-7-iodo-4,1-benzoxazepin-2(3H)-thione

: 131637-58-6
rac-6-(2-fluorophenyl)-8-iodo-1-methyl-4H,6H-<1,2,4>triazolo<4,3-a><4,1>benzoxazepine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / tetrahydrofuran / 0.25 h / Ambient temperature

2: 2.) acetic acid / 1.) EtOH, reflux, 15 min, 2.) reflux, 15 min

With acetic acid; hydrazine; In tetrahydrofuran;
DOI:10.1021/jm00107a048