12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoic acid (5-amino-pentyl)-amide

Base Information

• Chemical Name: 12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoic acid (5-amino-pentyl)-amide
• CAS No.: 872854-03-0
• Molecular Formula: C₃₁H₄₅ClN₄O₂
• Molecular Weight: 541.177
• Mol file: 872854-03-0.mol

Synonyms:12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoic acid (5-amino-pentyl)-amide

Chemical Property of 12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoic acid (5-amino-pentyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoic acid (5-amino-pentyl)-amide

There total 1 articles about 12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoic acid (5-amino-pentyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) → 12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoic acid (5-amino-pentyl)-amide (872854-03-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / triethylamine; 1-hydroxybenzotriazole; N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide / dimethylformamide / 24 h / 20 °C

2: 40 percent / diethylamine; tetrakis(triphenylphosphine)palladium / CH₂Cl₂ / 2 h / 20 °C

3: 82 percent / 4-methylmorpholine; phenol / 2 h / 100 °C

4: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; triethylamine; trifluoroacetic acid; phenol; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2005.07.015

Reference yield: 81.0%

12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoic acid (5-amino-pentyl)-amide (872854-03-0) + 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid N-succinimidyl ester (64987-85-5) → 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoylamino]-pentyl}-amide (872854-01-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.ejmech.2005.07.015

upstream raw materials:

5-tert-butoxycarbonylamino-1-aminopentane

Downstream raw materials:

4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {5-[12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoylamino]-pentyl}-amide