Technology Process of C21H30O5
There total 7 articles about C21H30O5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tert-butyldimethylsilyl chloride; lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 3.5h;
Reagent/catalyst;
Temperature;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1016/j.tet.2014.03.028
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C
2: water; lithium hydroxide / methanol / 14 h / 0 - 20 °C
3: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere
4: lithium diisopropyl amide; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tert-butyldimethylsilyl chloride / tetrahydrofuran / 10 h / -78 °C / Inert atmosphere
With
dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; palladium 10% on activated carbon; water; hydrogen; tert-butyldimethylsilyl chloride; dicyclohexyl-carbodiimide; lithium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
3: |Steglich Esterification / 4: |Claisen-Ireland Rearrangement;
DOI:10.1016/j.tet.2014.03.028
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere
1.2: 0.75 h / 0 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 2 h / -40 - 20 °C / Inert atmosphere
3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere
4.1: lithium diisopropyl amide; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tert-butyldimethylsilyl chloride / tetrahydrofuran / 10 h / -78 °C / Inert atmosphere
With
dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; sodium hydride; tert-butyldimethylsilyl chloride; dicyclohexyl-carbodiimide; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; mineral oil;
3.1: |Steglich Esterification / 4.1: |Claisen-Ireland Rearrangement;
DOI:10.1016/j.tet.2014.03.028
