2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester

Base Information

Chemical Name:2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester
CAS No.:1396006-74-8
Molecular Formula:C₁₉H₁₉N₃O₂
Molecular Weight:321.379
Hs Code.:

Synonyms:2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester

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Chemical Property of 2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester

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Technology Process of 2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester

There total 3 articles about 2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.7%

: 142598-53-6
2-methyl-4-phenyl-2H-pyrazole-3-carboxylic acid

: 1517-69-7
(R)-1-phenylethanol

: 1396006-74-8
2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃; for 1h;

Reference yield:

: 23097-85-0
methyl 2-methyl-4-phenyl-2H-pyrazole-3-carboxylate

: 1396006-74-8
2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran / 2 h / 60 °C

2: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 80 °C

With diphenyl phosphoryl azide; triethylamine; lithium hydroxide; In tetrahydrofuran; toluene;

Reference yield:

: 98-80-6
phenylboronic acid

: 1396006-74-8
2-methyl-4-phenyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; water / 2 h / 60 °C / Inert atmosphere

3: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 1: |Suzuki Coupling / 3: |Curtius Rearrangement;
DOI:10.1021/jm301022v