4-{4-[(2-amino-6-chloropyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile

Base Information

Chemical Name:4-{4-[(2-amino-6-chloropyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile
CAS No.:912471-76-2
Molecular Formula:C₁₆H₁₁ClN₆O
Molecular Weight:338.756
Hs Code.:

Synonyms:4-{4-[(2-amino-6-chloropyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile

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Chemical Property of 4-{4-[(2-amino-6-chloropyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile

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Technology Process of 4-{4-[(2-amino-6-chloropyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile

There total 2 articles about 4-{4-[(2-amino-6-chloropyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 630125-69-8
4-(4-amino-phenoxy)-pyridine-2-carbonitrile

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 912471-76-2
4-{4-[(2-amino-6-chloropyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile

Guidance literature:: In water; isopropyl alcohol; at 91 ℃;

Reference yield:

: 19235-89-3
4-chloro-pyridine-2-carbonitrile

: 912471-76-2
4-{4-[(2-amino-6-chloropyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / ISOPROPYLAMIDE

1.2: 90 °C

2.1: water; isopropyl alcohol / 4 h / 91 °C

With potassium tert-butylate; In ISOPROPYLAMIDE; water; isopropyl alcohol;

Reference yield:

: 912471-76-2
4-{4-[(2-amino-6-chloropyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile

: 13922-41-3
1-Naphthylboronic acid

: C₂₆H₁₈N₆O

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl acetamide; water; at 150 ℃; Inert atmosphere; microwave irradiation;