4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine

Base Information

Chemical Name:4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine
CAS No.:1609258-89-0
Molecular Formula:C₁₉H₁₈N₄O
Molecular Weight:318.378
Hs Code.:

Synonyms:4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine

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Chemical Property of 4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine

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Technology Process of 4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine

There total 5 articles about 4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1609259-45-1
{4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridin-1-yl}methanol

: 1609258-89-0
4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: With water; potassium carbonate; In acetonitrile; at 80 - 85 ℃; for 24h;

Reference yield:

: 1609259-43-9
4-(4-bromo-3-methylphenoxy)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[3,2-c]pyridine

: 1609258-89-0
4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 1 h / 20 - 120 °C

2: potassium carbonate / trifluoroacetic acid / 1 h / 80 °C

3: potassium carbonate; water / acetonitrile / 24 h / 80 - 85 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; In 1,4-dioxane; water; acetonitrile; trifluoroacetic acid;

Reference yield:

: 60290-21-3
4-chloro-1H-pyrrolo-[3,2-c]-pyridine

: 1609258-89-0
4-[4-(1,4-dimethyl-1H-pyrazol-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

1.2: 0.25 h / 0 °C

2.1: 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; palladium diacetate; caesium carbonate / 1,4-dioxane / 18 h / 130 °C / Sealed tube

3.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 1 h / 20 - 120 °C

4.1: potassium carbonate / trifluoroacetic acid / 1 h / 80 °C

5.1: potassium carbonate; water / acetonitrile / 24 h / 80 - 85 °C

With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; palladium diacetate; sodium hydride; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; trifluoroacetic acid; mineral oil;