2-benzyl-2-tert-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester

Base Information

Chemical Name:2-benzyl-2-tert-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester
CAS No.:1026522-06-4
Molecular Formula:C₂₀H₃₀N₂O₆
Molecular Weight:394.468
Hs Code.:

2-benzyl-2-<i>tert</i>-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester

Synonyms:2-benzyl-2-tert-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester

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Chemical Property of 2-benzyl-2-tert-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester

Chemical Property:

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Technology Process of 2-benzyl-2-tert-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester

There total 7 articles about 2-benzyl-2-tert-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 143140-36-7
(R)-N-(tert-butoxycarbonyl)-α-formylmethyl-phenylalanine methyl ester

: 1026522-06-4
2-benzyl-2-tert-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester

Guidance literature:: glycine ethyl ester hydrochloride; (R)-N-(tert-butoxycarbonyl)-α-formylmethyl-phenylalanine methyl ester; With sodium acetate; In methanol; at 20 ℃;

With sodium cyanoborohydride; In methanol; Further stages.;
DOI:10.1021/jm020441o

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1026522-06-4
2-benzyl-2-tert-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / tetrahydrofuran / 48 h / Heating

2.1: O₃; MeOH / CH₂Cl₂ / -78 °C

2.2: 80 percent / Me₂S / methanol; CH₂Cl₂ / -78 - 20 °C

3.1: NaOAc; 4A MS / methanol / 20 °C

3.2: NaCNBH₃ / methanol

With methanol; sodium acetate; ozone; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm020441o

Reference yield:

: 143140-35-6
(S)-N-(tert-butoxycarbonyl)-α-allyl-phenylalanine methyl ester

: 1026522-06-4
2-benzyl-2-tert-butoxycarbonylamino-4-(methoxycarbonylmethyl-amino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₃; MeOH / CH₂Cl₂ / -78 °C

1.2: 80 percent / Me₂S / methanol; CH₂Cl₂ / -78 - 20 °C

2.1: NaOAc; 4A MS / methanol / 20 °C

2.2: NaCNBH₃ / methanol

With methanol; sodium acetate; ozone; In methanol; dichloromethane;
DOI:10.1021/jm020441o