trans-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic acid

Base Information

Chemical Name:trans-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic acid
CAS No.:22613-99-6
Molecular Formula:C₁₁H₁₂O₃
Molecular Weight:192.214
Hs Code.:
Mol file:22613-99-6.mol

Synonyms:Cyclopropanecarboxylicacid, 2-(hydroxymethyl)-1-phenyl-, trans- (8CI)

Suppliers and Price of trans-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1R,2R)-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylicAcid
2.5mg
$ 165.00

TRC
(1R,2R)-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylicAcid
25mg
$ 1320.00

Medical Isotopes, Inc.
(1R,2R)-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylicAcid
2.5 mg
$ 650.00

Total 19 raw suppliers

Chemical Property of trans-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic acid

Chemical Property:

Melting Point:130oC
Boiling Point:382.1±25.0 °C(Predicted)
PKA:4.38±0.50(Predicted)
PSA：57.53000
Density:1.310
LogP:1.02120

Purity/Quality:

98%Min ^*data from raw suppliers

(1R,2R)-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (1R,2R)-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic Acid is an impurity in the synthesis of Milnacipran (M344600). Milnacipran is an antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.

Technology Process of trans-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic acid

There total 6 articles about trans-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 67843-74-7,24969-06-0,13403-37-7
(S)-epichlorohydrin

: 140-29-4
phenylacetonitrile

: 22613-99-6,66823-04-9,70209-83-5,96847-50-6,96847-51-7
(1S,2S)-2-(hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

: 96847-52-8
(1R,2S)-2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane

Guidance literature:: phenylacetonitrile; With sodium amide; In benzene; at 0 - 20 ℃; for 3h; Inert atmosphere;

(S)-epichlorohydrin; In benzene; at 0 - 20 ℃; for 2h; Further stages; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01584

Reference yield: 5.2%

: 51594-55-9,24969-06-0,13403-37-7
(R)-(-)-epichlorohydrin

: 140-29-4
phenylacetonitrile

: 22613-99-6,66823-04-9,70209-83-5,96847-50-6,96847-51-7
(1S,2S)-2-(hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

Guidance literature:: (R)-(-)-epichlorohydrin; phenylacetonitrile; With sodium amide; In toluene; at 0 - 5 ℃;

With water; potassium hydroxide; In toluene; Reflux;