3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]acrylic acid ethyl ester

Base Information

• Chemical Name: 3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]acrylic acid ethyl ester
• CAS No.: 1044504-37-1
• Molecular Formula: C₁₇H₁₈N₂O₄
• Molecular Weight: 314.341
• Mol file: 1044504-37-1.mol

Synonyms:3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]acrylic acid ethyl ester

Chemical Property of 3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]acrylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]acrylic acid ethyl ester

There total 1 articles about 3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-methyl-1-(4-iodobenzyl)-1H-pyrimidine-2,4-dione (886836-56-2) + ethyl acrylate (140-88-5,9003-32-1) → 3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]acrylic acid ethyl ester (1044504-37-1)

Guidance literature:

With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In acetonitrile; at 90 ℃; for 18h;

DOI:10.1016/j.bmc.2008.04.045

Reference yield: 91.0%

3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]acrylic acid ethyl ester (1044504-37-1) → 3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]propionic acid ethyl ester (849502-13-2)

Guidance literature:

With hydrogen; palladium; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2008.04.045

Reference yield: 84.0%

3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]acrylic acid ethyl ester (1044504-37-1) → C15H15N3O3

Guidance literature:

With ammonium hydroxide; at 20 ℃;

DOI:10.1016/j.bmc.2008.04.045

upstream raw materials:

5-methyl-1-(4-iodobenzyl)-1H-pyrimidine-2,4-dione

ethyl acrylate

Downstream raw materials:

3-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)phenyl]propionic acid ethyl ester