(1R,2R)-trans-2-phenylcyclopropane-1-carboxyl chloride

Base Information

• Chemical Name: (1R,2R)-trans-2-phenylcyclopropane-1-carboxyl chloride
• CAS No.: 37107-48-5
• Molecular Formula: C₁₀H₉ClO
• Molecular Weight: 180.634
• Mol file: 37107-48-5.mol

Synonyms:(1R,2R)-trans-2-phenylcyclopropane-1-carboxyl chloride

Chemical Property of (1R,2R)-trans-2-phenylcyclopropane-1-carboxyl chloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-trans-2-phenylcyclopropane-1-carboxyl chloride

There total 11 articles about (1R,2R)-trans-2-phenylcyclopropane-1-carboxyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

trans-2-phenylcyclopropane-1-carboxylic acid (939-90-2) → (1SR,2SR)-2-phenylcyclopropanecarbonyl chloride (939-87-7,5685-36-9,37107-48-5,42916-08-5,42916-12-1,42916-13-2,62624-90-2,78738-39-3)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; benzene; for 3h; Heating;

DOI:10.1021/ja00053a031

Reference yield:

(E)-3-phenylacrylic acid (140-10-3) → (1SR,2SR)-2-phenylcyclopropanecarbonyl chloride (939-87-7,5685-36-9,37107-48-5,42916-08-5,42916-12-1,42916-13-2,62624-90-2,78738-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: CuCr₂O₄; 1-butyl-3-methylimidazolium hydroxide / tetrahydrofuran / 4 h / 20 - 50 °C

2: chloroformic acid ethyl ester; triethylamine / toluene / 4 h / Cooling with ice

With 1-butyl-3-methylimidazolium hydroxide; CuCr₂O₄; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1007/s11164-016-2572-1

Reference yield:

2-phenyl-cyclopropanecarboxylic acid (5685-38-1) → 2-phenyl-1-cyclopropanecarbonyl chloride (939-87-7,5685-36-9,37107-48-5,42916-08-5,42916-12-1,42916-13-2,62624-90-2,78738-39-3)

Guidance literature:

With thionyl chloride;

DOI:10.1002/hlca.19860690720

upstream raw materials:

(1S*,2R*)-2-phenylcyclopropane-1-carboxylic acid

trans-2-phenylcyclopropane-1-carboxylic acid

2-phenyl-cyclopropanecarboxylic acid

ethyl 2-phenylcyclopropylcarboxylate

Downstream raw materials:

2,6-di(tert-butyl)-4-methylphenyl 2-phenylcyclopropanecarboxylate

(3-Phenyl-propen-⁽¹⁾-yl)-mesitylketon